RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer

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RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates wi...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 2017

ISSN: 0890-9369,1549-5477

DOI: 10.1101/gad.304162.117